«IPHAR» R&D center performs preclinical studies in accordance with the principles of Good Laboratory Practice (GLP).
The R&D center is an Accredited Collective Use Center of Skolkovo Technopark.
The Head of «IPHAR» R&D center guarantees that GLP principles would be fully implemented in accordance with Quality Assurance Program, and that the Quality Assurance Department has no conflicts of interests.
Organization structure of the R&D center is based on quality management principles, absence of conflicts of interests and independent control of preclinical studies.
The R&D center includes Quality Assurance Department, Pharmacological Research Department, Analytical Chemistry Laboratory, Pharmacy Departmeny, Veterinary Department, 2 animal facilities: for conventional and SPF-animals (mice, rats, rabbits and guinea pigs):
Animal health is monitored in accordance with FELASA requirements in accredited laboratories.
Extensive drug development experience, modern research infrastructure, regular staff training and conformance to modern international requirements allow us to perform preclinical research at high level and in accordance with the rules and principles of Good Laboratory Practice.
«IPHAR» R&D center offers its services for studying efficacy and safety of drugs.
General toxicity studies:
- single and repeat dose toxicity.
Specific toxicity studies:
- reproductive toxicity;
- mutagenicity;
- immunotoxicity;
- allergenic properties;
- carcinogenicity.
Specific activity of different types of drugs:
- anti-inflammatory;
- analgesic;
- psychoactive;
- antiplatelet;
- anti-ischemic;
- nootropic;
- antiviral;
- anti-tumor;
- anticoagulant;
- antiarrhythmic;
- anticancer;
- immunotropic;
- actoprotective.
Pharmacokinetic studies using HPLC and GC-MS:
- pharmacokinetic profile in the blood, bioavailability;
- organ and tissue distribution;
- metabolism;
- excretion.
